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Reviewed December 2008
What is the official name of the IDUA gene?
The official name of this gene is “iduronidase, alpha-L-.”
IDUA is the gene's official symbol. The IDUA gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the IDUA gene?
The IDUA gene provides instructions for producing an enzyme called alpha-L-iduronidase, which is essential for the breakdown of large sugar molecules called glycosaminoglycans (GAGs). Through a process called hydrolysis, alpha-L-iduronidase uses water molecules to break down a molecule known as unsulfated alpha-L-iduronic acid, which is present in two GAGs called heparan sulfate and dermatan sulfate. Alpha-L-iduronidase is located in lysosomes, compartments within cells that digest and recycle different types of molecules.
How are changes in the IDUA gene related to health conditions?
Where is the IDUA gene located?
Cytogenetic Location: 4p16.3
Molecular Location on chromosome 4: base pairs 980,784 to 998,316
The IDUA gene is located on the short (p) arm of chromosome 4 at position 16.3.
More precisely, the IDUA gene is located from base pair 980,784 to base pair 998,316 on chromosome 4.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about IDUA?
You and your healthcare professional may find the following resources about IDUA helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the IDUA gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding IDUA?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (7 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.