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Reviewed September 2010
What is the official name of the IKBKG gene?
The official name of this gene is “inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma.”
IKBKG is the gene's official symbol. The IKBKG gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the IKBKG gene?
The IKBKG gene (also known as NEMO) provides instructions for making a protein that plays a critical role in regulating nuclear factor-kappa-B. Nuclear factor-kappa-B is a group of related proteins (a protein complex) that binds to DNA and controls the activity of other genes.
Within cells, the IKBKG protein interacts with two enzymes, IKK-alpha and IKK-beta, to activate nuclear factor-kappa-B. The activated factor then moves into the nucleus and binds to DNA. Nuclear factor-kappa-B regulates the activity of multiple genes, including genes that control the body's immune responses and inflammatory reactions. It also protects the cell from certain signals that would otherwise cause it to self-destruct (undergo apoptosis).
How are changes in the IKBKG gene related to health conditions?
Where is the IKBKG gene located?
Cytogenetic Location: Xq28
Molecular Location on the X chromosome: base pairs 153,770,458 to 153,793,260
The IKBKG gene is located on the long (q) arm of the X chromosome at position 28.
More precisely, the IKBKG gene is located from base pair 153,770,458 to base pair 153,793,260 on the X chromosome.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about IKBKG?
You and your healthcare professional may find the following resources about IKBKG helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the IKBKG gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding IKBKG?
apoptosis ; bacteria ; B-cells ; cell ; deficiency ; DNA ; dysplasia ; gene ; immune system ; immunodeficiency ; infection ; inheritance ; kinase ; lymphedema ; mutation ; mycobacteria ; mycobacterium ; nucleus ; pattern of inheritance ; protein ; rearrangement ; respiratory ; susceptibility ; tuberculosis
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (14 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.