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IKZF3

IKZF3

The information on this page was automatically extracted from online scientific databases.

What is the official name of the IKZF3 gene?

The official name of this gene is “IKAROS family zinc finger 3 (Aiolos).”

IKZF3 is the gene's official symbol. The IKZF3 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the IKZF3 gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]

From UniProtThis link leads to a site outside Genetics Home Reference.:

Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.

How are changes in the IKZF3 gene related to health conditions?

Genetics Home Reference provides information about rheumatoid arthritis, which is associated with changes in the IKZF3 gene.
UniProt and NCBI Gene cite these articles in OMIM, a catalog designed for genetics professionals and researchers that provides detailed information about genetic conditions and genes.
 Article
Number
Main Topic

Where is the IKZF3 gene located?

Cytogenetic Location: 17q21

Molecular Location on chromosome 17: base pairs 39,757,714 to 39,864,187

The IKZF3 gene is located on the long (q) arm of chromosome 17 at position 21.

The IKZF3 gene is located on the long (q) arm of chromosome 17 at position 21.

More precisely, the IKZF3 gene is located from base pair 39,757,714 to base pair 39,864,187 on chromosome 17.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about IKZF3?

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the IKZF3 gene or gene products?

  • AIO
  • AIOLOS
  • ZNFN1A3

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding IKZF3?

apoptosis ; cell ; chromatin ; chromatin remodeling ; differentiation ; gene ; gene expression ; gene product ; hematopoietic ; isoforms ; lymphocyte ; proliferation ; protein ; T-cells ; transcription ; transcription factor

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Published: July 21, 2014