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IL2

IL2

The information on this page was automatically extracted from online scientific databases.

What is the official name of the IL2 gene?

The official name of this gene is “interleukin 2.”

IL2 is the gene's official symbol. The IL2 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the IL2 gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]

From UniProtThis link leads to a site outside Genetics Home Reference.:

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

How are changes in the IL2 gene related to health conditions?

Genetics Home Reference provides information about rheumatoid arthritis, which is associated with changes in the IL2 gene.
UniProtThis link leads to a site outside Genetics Home Reference. provides the following information about the IL2 gene's known or predicted involvement in human disease.

A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.

OMIM.orgThis link leads to a site outside Genetics Home Reference., a catalog designed for genetics professionals and researchers, provides the following information about the IL2 gene and its association with health conditions.
OMIM
Number
Title

Where is the IL2 gene located?

Cytogenetic Location: 4q26-q27

Molecular Location on chromosome 4: base pairs 122,451,469 to 122,456,494

The IL2 gene is located on the long (q) arm of chromosome 4 between positions 26 and 27.

The IL2 gene is located on the long (q) arm of chromosome 4 between positions 26 and 27.

More precisely, the IL2 gene is located from base pair 122,451,469 to base pair 122,456,494 on chromosome 4.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about IL2?

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the IL2 gene or gene products?

  • IL-2
  • lymphokine
  • TCGF

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding IL2?

acute ; acute lymphoblastic leukemia ; B-cells ; cell ; cell proliferation ; colitis ; cytokine ; gene ; glioma ; immune response ; killer cells ; leukemia ; mutation ; natural killer cells ; polymorphism ; proliferation ; protein ; receptor ; T-cells ; translocation

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Published: December 22, 2014