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Reviewed February 2009
What is the official name of the IL23R gene?
The official name of this gene is “interleukin 23 receptor.”
IL23R is the gene's official symbol. The IL23R gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the IL23R gene?
The IL23R gene provides instructions for making a protein called the interleukin 23 receptor. This protein is embedded in the cell membrane of several types of immune system cells, including T cells, natural killer (NK) cells, monocytes, and dendritic cells. These cells identify foreign substances and defend the body against infection and disease.
At the cell surface, the interleukin 23 receptor interacts with a protein called interleukin 23. These two proteins fit together like a lock and its key. Interleukin 23 is a cytokine, which is a type of protein that regulates the activity of immune system cells. When interleukin 23 binds to its receptor, it triggers a series of chemical signals inside the cell. These signals promote inflammation and help coordinate the immune system's response to foreign invaders such as bacteria and viruses.
Does the IL23R gene share characteristics with other genes?
The IL23R gene belongs to a family of genes called IL (interleukin and interleukin receptor genes).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the IL23R gene related to health conditions?
Genetics Home Reference provides information about psoriatic arthritis, which is also associated with changes in the IL23R gene.
Where is the IL23R gene located?
Cytogenetic Location: 1p31.3
Molecular Location on chromosome 1: base pairs 67,632,168 to 67,725,661
The IL23R gene is located on the short (p) arm of chromosome 1 at position 31.3.
More precisely, the IL23R gene is located from base pair 67,632,168 to base pair 67,725,661 on chromosome 1.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about IL23R?
You and your healthcare professional may find the following resources about IL23R helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the IL23R gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding IL23R?
amino acid ; arthritis ; autoimmune ; bacteria ; cell ; cell membrane ; chronic ; cytokine ; gene ; immune response ; immune system ; infection ; inflammation ; protein ; psoriasis ; receptor ; spondylitis
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (12 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.