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IL2RB

IL2RB

The information on this page was automatically extracted from online scientific databases.

What is the official name of the IL2RB gene?

The official name of this gene is “interleukin 2 receptor, beta.”

IL2RB is the gene's official symbol. The IL2RB gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the IL2RB gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. [provided by RefSeq, Jul 2008]

From UniProtThis link leads to a site outside Genetics Home Reference.:

Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.

How are changes in the IL2RB gene related to health conditions?

Genetics Home Reference provides information about rheumatoid arthritis, which is associated with changes in the IL2RB gene.
OMIM.orgThis link leads to a site outside Genetics Home Reference., a catalog designed for genetics professionals and researchers, provides the following information about the IL2RB gene and its association with health conditions.
OMIM
Number
Title

Where is the IL2RB gene located?

Cytogenetic Location: 22q13.1

Molecular Location on chromosome 22: base pairs 37,125,837 to 37,149,921

The IL2RB gene is located on the long (q) arm of chromosome 22 at position 13.1.

The IL2RB gene is located on the long (q) arm of chromosome 22 at position 13.1.

More precisely, the IL2RB gene is located from base pair 37,125,837 to base pair 37,149,921 on chromosome 22.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about IL2RB?

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the IL2RB gene or gene products?

  • CD122
  • IL15RB
  • P70-75

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding IL2RB?

cell ; endocytosis ; gene ; monomer ; protein ; receptor ; signal transduction ; subunit ; transduction

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Published: December 16, 2014