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IRAK1

IRAK1

The information on this page was automatically extracted from online scientific databases.

What is the official name of the IRAK1 gene?

The official name of this gene is “interleukin-1 receptor-associated kinase 1.”

IRAK1 is the gene's official symbol. The IRAK1 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the IRAK1 gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

From UniProtThis link leads to a site outside Genetics Home Reference.:

Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3.

How are changes in the IRAK1 gene related to health conditions?

Genetics Home Reference provides information about rheumatoid arthritis, which is associated with changes in the IRAK1 gene.
UniProt and NCBI Gene cite these articles in OMIM, a catalog designed for genetics professionals and researchers that provides detailed information about genetic conditions and genes.
 Article
Number
Main Topic

Where is the IRAK1 gene located?

Cytogenetic Location: Xq28

Molecular Location on the X chromosome: base pairs 154,010,505 to 154,019,890

The IRAK1 gene is located on the long (q) arm of the X chromosome at position 28.

The IRAK1 gene is located on the long (q) arm of the X chromosome at position 28.

More precisely, the IRAK1 gene is located from base pair 154,010,505 to base pair 154,019,890 on the X chromosome.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about IRAK1?

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the IRAK1 gene or gene products?

  • IRAK
  • pelle

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding IRAK1?

cell ; degradation ; domain ; gene ; IFN ; immune response ; isoforms ; kinase ; nucleus ; phosphorylation ; protein ; receptor ; serine ; threonine ; transcript ; transcription ; transcription factor ; translocation ; ubiquitin

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Published: October 9, 2014