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References

These sources were used to develop the Genetics Home Reference gene summary on the IRGM gene.

Deretic V. Autophagy as an immune defense mechanism. Curr Opin Immunol. 2006 Aug;18(4):375-82. Epub 2006 Jun 19. Review. PubMed citation
Entrez Gene
MacMicking JD. Immune control of phagosomal bacteria by p47 GTPases. Curr Opin Microbiol. 2005 Feb;8(1):74-82. Review. PubMed citation
Parkes M, Barrett JC, Prescott NJ, Tremelling M, Anderson CA, Fisher SA, Roberts RG, Nimmo ER, Cummings FR, Soars D, Drummond H, Lees CW, Khawaja SA, Bagnall R, Burke DA, Todhunter CE, Ahmad T, Onnie CM, McArdle W, Strachan D, Bethel G, Bryan C, Lewis CM, Deloukas P, Forbes A, Sanderson J, Jewell DP, Satsangi J, Mansfield JC; Wellcome Trust Case Control Consortium, Cardon L, Mathew CG. Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet. 2007 Jul;39(7):830-2. Epub 2007 Jun 6. PubMed citation
Singh SB, Davis AS, Taylor GA, Deretic V. Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science. 2006 Sep 8;313(5792):1438-41. Epub 2006 Aug 3. PubMed citation

Reviewed: August 2007

Published: May 13, 2013