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Reviewed November 2009
What is the official name of the ISCU gene?
The official name of this gene is “iron-sulfur cluster assembly enzyme.”
ISCU is the gene's official symbol. The ISCU gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the ISCU gene?
The ISCU gene provides instructions for making a protein called the iron-sulfur cluster assembly enzyme. As its name suggests, this enzyme is involved in the formation of clusters of iron and sulfur atoms (Fe-S clusters). Specifically, the enzyme acts as a platform, or scaffold, for the assembly of these clusters. Fe-S clusters are critical for the function of many different proteins, including those needed for DNA repair and the regulation of iron levels. Proteins containing Fe-S clusters are also necessary for energy production within mitochondria, which are the cell structures that convert the energy from food into a form that cells can use.
How are changes in the ISCU gene related to health conditions?
Where is the ISCU gene located?
Cytogenetic Location: 12q24.1
Molecular Location on chromosome 12: base pairs 108,955,238 to 108,963,159
The ISCU gene is located on the long (q) arm of chromosome 12 at position 24.1.
More precisely, the ISCU gene is located from base pair 108,955,238 to base pair 108,963,159 on chromosome 12.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about ISCU?
You and your healthcare professional may find the following resources about ISCU helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the ISCU gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding ISCU?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (7 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.