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Reviewed April 2007
What is the official name of the IVD gene?
The official name of this gene is “isovaleryl-CoA dehydrogenase.”
IVD is the gene's official symbol. The IVD gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the IVD gene?
The IVD gene provides instructions for making an enzyme called isovaleryl-CoA dehydrogenase. This enzyme plays an essential role in processing proteins obtained from the diet. Normally, the body breaks down proteins from food into smaller parts called amino acids. Amino acids can be further processed to provide energy for growth and development. In cells throughout the body, isovaleryl-CoA dehydrogenase is found within specialized structures called mitochondria. Mitochondria convert energy from food to a form that cells can use.
Isovaleryl-CoA dehydrogenase helps process a particular amino acid called leucine. Specifically, this enzyme is responsible for the third step in the breakdown of leucine. This step is a chemical reaction that converts a molecule called isovaleryl-CoA to another molecule, 3-methylcrotonyl-CoA. Additional chemical reactions convert 3-methylcrotonyl-CoA into molecules that are used for energy.
How are changes in the IVD gene related to health conditions?
Where is the IVD gene located?
Cytogenetic Location: 15q14-q15
Molecular Location on chromosome 15: base pairs 40,697,685 to 40,713,511
The IVD gene is located on the long (q) arm of chromosome 15 between positions 14 and 15.
More precisely, the IVD gene is located from base pair 40,697,685 to base pair 40,713,511 on chromosome 15.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about IVD?
You and your healthcare professional may find the following resources about IVD helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the IVD gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding IVD?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (7 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.