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Reviewed January 2007
What is the official name of the KCNE2 gene?
The official name of this gene is “potassium voltage-gated channel, Isk-related family, member 2.”
KCNE2 is the gene's official symbol. The KCNE2 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the KCNE2 gene?
The KCNE2 gene provides instructions for making a protein that regulates the activity of potassium channels. These channels, which transport positively charged atoms (ions) of potassium into and out of cells, play a key role in a cell's ability to generate and transmit electrical signals.
The specific function of a potassium channel depends on its protein components and its location in the body. The KCNE2 protein regulates several ion channels, including a channel made up of proteins produced by the KCNH2 gene. Channels made with the KCNH2 protein are present in heart (cardiac) muscle, where they transport potassium ions out of cells. This form of ion transport is involved in recharging the cardiac muscle after each heartbeat to maintain a regular rhythm.
The proteins produced from the KCNH2 and KCNE2 genes interact to form a functional potassium channel. Four alpha subunits, each produced from the KCNH2 gene, form the structure of each channel. One beta subunit, produced from the KCNE2 gene, binds to the channel and regulates its activity.
Does the KCNE2 gene share characteristics with other genes?
The KCNE2 gene belongs to a family of genes called KCN (potassium channels).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the KCNE2 gene related to health conditions?
Where is the KCNE2 gene located?
Cytogenetic Location: 21q22.12
Molecular Location on chromosome 21: base pairs 35,736,322 to 35,743,439
The KCNE2 gene is located on the long (q) arm of chromosome 21 at position 22.12.
More precisely, the KCNE2 gene is located from base pair 35,736,322 to base pair 35,743,439 on chromosome 21.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about KCNE2?
You and your healthcare professional may find the following resources about KCNE2 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the KCNE2 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding KCNE2?
amino acid ; arrhythmia ; atrial ; atrial fibrillation ; cardiac ; cardiac arrest ; cell ; channel ; fainting ; familial ; fibrillation ; gene ; ions ; ion transport ; long QT syndrome ; mutation ; peptide ; potassium ; protein ; psychotic ; subunit ; syncope ; syndrome ; voltage
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (11 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.