|http://ghr.nlm.nih.gov/ A service of the U.S. National Library of Medicine®|
The official name of this gene is “potassium voltage-gated channel, Isk-related family, member 2.”
KCNE2 is the gene's official symbol. The KCNE2 gene is also known by other names, listed below.
The KCNE2 gene provides instructions for making a protein that regulates the activity of potassium channels. These channels, which transport positively charged atoms (ions) of potassium into and out of cells, play a key role in a cell's ability to generate and transmit electrical signals.
The specific function of a potassium channel depends on its protein components and its location in the body. The KCNE2 protein regulates several ion channels, including a channel made up of proteins produced by the KCNH2 gene. Channels made with the KCNH2 protein are present in heart (cardiac) muscle, where they transport potassium ions out of cells. This form of ion transport is involved in recharging the cardiac muscle after each heartbeat to maintain a regular rhythm.
The proteins produced from the KCNH2 and KCNE2 genes interact to form a functional potassium channel. Four alpha subunits, each produced from the KCNH2 gene, form the structure of each channel. One beta subunit, produced from the KCNE2 gene, binds to the channel and regulates its activity.
The KCNE2 gene belongs to a family of genes called KCN (potassium channels).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? (http://ghr.nlm.nih.gov/handbook/howgeneswork/genefamilies) in the Handbook.
More than 10 mutations in the KCNE2 gene have been identified in people with Romano-Ward syndrome. These mutations change a single protein building block (amino acid) in the KCNE2 protein, which alters the protein's ability to regulate potassium channels in cardiac muscle cells. The channels open more slowly and close more rapidly than usual, decreasing the flow of potassium ions out of these cells. This disruption in ion transport causes an abnormal heart rhythm (arrhythmia) that increases the risk of fainting (syncope) and sudden death.
A mutation in the KCNE2 gene is associated with rare cases of an abnormal heart rhythm called familial atrial fibrillation. In a small number of people with this condition, researchers have found a mutation that replaces the amino acid arginine with the amino acid cysteine at position 27 of the protein made by the KCNE2 gene (written as Arg27Cys or R27C). In cardiac muscle cells, this mutation appears to increase the flow of potassium ions through certain channels regulated by the KCNE2 protein. The enhanced ion transport may alter the heart's normal rhythm. Researchers are working to determine whether the R27C mutation is the direct cause of atrial fibrillation in these affected individuals.
Certain drugs, including medications used to treat arrhythmias, infections, seizures, and psychotic disorders, can lead to another type of abnormal heart rhythm in some people. This drug-induced heart condition, which is known as acquired long QT syndrome, increases the risk of cardiac arrest and sudden death. A small percentage of cases of acquired long QT syndrome occur in people who have an underlying mutation in the KCNE2 gene.
Cytogenetic Location: 21q22.12
Molecular Location on chromosome 21: base pairs 35,736,322 to 35,743,439
The KCNE2 gene is located on the long (q) arm of chromosome 21 at position 22.12.
More precisely, the KCNE2 gene is located from base pair 35,736,322 to base pair 35,743,439 on chromosome 21.
See How do geneticists indicate the location of a gene? (http://ghr.nlm.nih.gov/handbook/howgeneswork/genelocation) in the Handbook.
You and your healthcare professional may find the following resources about KCNE2 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
See How are genetic conditions and genes named? (http://ghr.nlm.nih.gov/handbook/mutationsanddisorders/naming) in the Handbook.
amino acid ; arrhythmia ; atrial ; atrial fibrillation ; cardiac ; cardiac arrest ; cell ; channel ; fainting ; familial ; fibrillation ; gene ; ions ; ion transport ; long QT syndrome ; mutation ; peptide ; potassium ; protein ; psychotic ; subunit ; syncope ; syndrome ; voltage
You may find definitions for these and many other terms in the Genetics Home Reference Glossary (http://www.ghr.nlm.nih.gov/glossary).
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.