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Reviewed November 2011
What is the official name of the KRT1 gene?
The official name of this gene is “keratin 1.”
KRT1 is the gene's official symbol. The KRT1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the KRT1 gene?
The KRT1 gene provides instructions for making a protein called keratin 1. Keratins are a group of tough, fibrous proteins that form the structural framework of cells called keratinocytes that make up the skin, hair, and nails. Keratin 1 is produced in keratinocytes in the outer layer of the skin (the epidermis), including the skin on the palms of the hands and soles of the feet.
The keratin 1 protein partners with another keratin protein, either keratin 9 or keratin 10, to form molecules called keratin intermediate filaments. These filaments assemble into strong networks that provide strength and resiliency to the skin and protect it from being damaged by friction and other everyday physical stresses.
Does the KRT1 gene share characteristics with other genes?
The KRT1 gene belongs to a family of genes called KRT (keratins).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the KRT1 gene related to health conditions?
Where is the KRT1 gene located?
Cytogenetic Location: 12q13.13
Molecular Location on chromosome 12: base pairs 53,068,519 to 53,074,190
The KRT1 gene is located on the long (q) arm of chromosome 12 at position 13.13.
More precisely, the KRT1 gene is located from base pair 53,068,519 to base pair 53,074,190 on chromosome 12.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about KRT1?
You and your healthcare professional may find the following resources about KRT1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the KRT1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding KRT1?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (13 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.