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Reviewed January 2010
What is the official name of the MPZ gene?
The official name of this gene is “myelin protein zero.”
MPZ is the gene's official symbol. The MPZ gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the MPZ gene?
The MPZ gene provides instructions for making a protein called myelin protein zero. It is the most abundant protein in myelin, a protective substance that covers nerves and promotes the efficient transmission of nerve impulses. Specialized cells called Schwann cells, which wrap around and insulate nerves, are the only cells that make myelin protein zero. Schwann cells are part of the peripheral nervous system which connects the brain and spinal cord to muscles and to sensory cells that detect sensations such as touch, pain, heat, and sound. Myelin protein zero is required for the proper formation and maintenance of myelin. This protein is an adhesion molecule, which means it acts like molecular glue. It plays a role in tightly packing the myelin around nerve cells (myelin compaction).
How are changes in the MPZ gene related to health conditions?
Where is the MPZ gene located?
Cytogenetic Location: 1q23.3
Molecular Location on chromosome 1: base pairs 161,304,734 to 161,309,971
The MPZ gene is located on the long (q) arm of chromosome 1 at position 23.3.
More precisely, the MPZ gene is located from base pair 161,304,734 to base pair 161,309,971 on chromosome 1.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about MPZ?
You and your healthcare professional may find the following resources about MPZ helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the MPZ gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding MPZ?
acids ; adhesion molecule ; axons ; congenital ; gene ; molecule ; motor ; nervous system ; neuropathy ; peripheral ; peripheral nervous system ; protein ; pupil ; Schwann cells ; sensory cells ; syndrome
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (12 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.