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Reviewed August 2010
What is the official name of the NAGLU gene?
The official name of this gene is “N-acetylglucosaminidase, alpha.”
NAGLU is the gene's official symbol. The NAGLU gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the NAGLU gene?
The NAGLU gene provides instructions for producing an enzyme called alpha-N-acetylglucosaminidase. This enzyme is located in lysosomes, compartments within cells that digest and recycle different types of molecules. Alpha-N-acetylglucosaminidase is involved in the step-wise breakdown of large molecules called glycosaminoglycans (GAGs). GAGs are composed of sugar molecules that are linked together to form a long string. To break down these large molecules, individual sugars are removed one at a time from one end of the molecule. Alpha-N-acetylglucosaminidase removes a sugar called N-acetylglucosamine when it is at the end of the GAG chain.
How are changes in the NAGLU gene related to health conditions?
Where is the NAGLU gene located?
Cytogenetic Location: 17q21
Molecular Location on chromosome 17: base pairs 40,687,950 to 40,696,466
The NAGLU gene is located on the long (q) arm of chromosome 17 at position 21.
More precisely, the NAGLU gene is located from base pair 40,687,950 to base pair 40,696,466 on chromosome 17.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about NAGLU?
You and your healthcare professional may find the following resources about NAGLU helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the NAGLU gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding NAGLU?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.