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Genetics Home Reference: your guide to understanding genetic conditions
http://ghr.nlm.nih.gov/     A service of the U.S. National Library of Medicine®

NR4A2

Reviewed March 2005

What is the official name of the NR4A2 gene?

The official name of this gene is “nuclear receptor subfamily 4, group A, member 2.”

NR4A2 is the gene's official symbol. The NR4A2 gene is also known by other names, listed below.

What is the normal function of the NR4A2 gene?

The NR4A2 gene provides instructions for making a protein found in the brain and the adrenal gland (the hormone-producing gland located on top of each kidney). In the brain, the NR4A2 protein plays a key role in prompting certain nerve cells to specialize (differentiate) and produce a chemical messenger called dopamine. Dopamine transmits messages that help the brain control physical movement and emotional behavior.

Does the NR4A2 gene share characteristics with other genes?

The NR4A2 gene belongs to a family of genes called NR (nuclear hormone receptors).

A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? (http://ghr.nlm.nih.gov/handbook/howgeneswork/genefamilies) in the Handbook.

Where is the NR4A2 gene located?

Cytogenetic Location: 2q22-q23

Molecular Location on chromosome 2: base pairs 156,324,431 to 156,332,774

The NR4A2 gene is located on the long (q) arm of chromosome 2 between positions 22 and 23.

The NR4A2 gene is located on the long (q) arm of chromosome 2 between positions 22 and 23.

More precisely, the NR4A2 gene is located from base pair 156,324,431 to base pair 156,332,774 on chromosome 2.

See How do geneticists indicate the location of a gene? (http://ghr.nlm.nih.gov/handbook/howgeneswork/genelocation) in the Handbook.

Where can I find additional information about NR4A2?

You and your healthcare professional may find the following resources about NR4A2 helpful.

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the NR4A2 gene or gene products?

  • HZF-3
  • NOT
  • NR4A2_HUMAN
  • nuclear receptor of T cells
  • nuclear receptor related 1
  • NURR1
  • RNR1
  • TINUR
  • transcriptionally inducible nuclear receptor

See How are genetic conditions and genes named? (http://ghr.nlm.nih.gov/handbook/mutationsanddisorders/naming) in the Handbook.

What glossary definitions help with understanding NR4A2?

dopamine ; gene ; hormone ; kidney ; protein ; receptor

You may find definitions for these and many other terms in the Genetics Home Reference Glossary (http://www.ghr.nlm.nih.gov/glossary).

References

  • Bassett MH, Suzuki T, Sasano H, White PC, Rainey WE. The orphan nuclear receptors NURR1 and NGFIB regulate adrenal aldosterone production. Mol Endocrinol. 2004 Feb;18(2):279-90. Epub 2003 Nov 26. (http://www.ncbi.nlm.nih.gov/pubmed/14645496?dopt=Abstract)
  • Hering R, Petrovic S, Mietz EM, Holzmann C, Berg D, Bauer P, Woitalla D, Müller T, Berger K, Krüger R, Riess O. Extended mutation analysis and association studies of Nurr1 (NR4A2) in Parkinson disease. Neurology. 2004 Apr 13;62(7):1231-2. (http://www.ncbi.nlm.nih.gov/pubmed/15079038?dopt=Abstract)
  • NCBI Gene (http://www.ncbi.nlm.nih.gov/gene/4929)
  • OMIM: NUCLEAR RECEPTOR SUBFAMILY 4, GROUP A, MEMBER 2 (http://omim.org/entry/601828)

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.

 
Reviewed: March 2005
Published: August 25, 2014