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Reviewed August 2013
What is the official name of the PIGV gene?
The official name of this gene is “phosphatidylinositol glycan anchor biosynthesis, class V.”
PIGV is the gene's official symbol. The PIGV gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the PIGV gene?
The PIGV gene provides instructions for making an enzyme called GPI mannosyltransferase 2. This enzyme takes part in a series of steps that produce a molecule called a glycosylphosphosphatidylinositol (GPI) anchor. Specifically, GPI mannosyltransferase 2 adds the second of three molecules of a complex sugar called mannose to the GPI anchor. This step takes place in the endoplasmic reticulum, which is a structure involved in protein processing and transport within cells. The complete GPI anchor attaches (binds) to various proteins in the endoplasmic reticulum. After the anchor and protein are bound, the anchor attaches itself to the outer surface of the cell membrane, ensuring that the protein will be available when it is needed.
Does the PIGV gene share characteristics with other genes?
The PIGV gene belongs to a family of genes called dolichyl D-mannosyl phosphate dependent mannosyltransferases (dolichyl D-mannosyl phosphate dependent mannosyltransferases). It also belongs to a family of genes called PIG (phosphatidylinositol glycan anchor biosynthesis).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the PIGV gene related to health conditions?
Where is the PIGV gene located?
Cytogenetic Location: 1p36.11
Molecular Location on chromosome 1: base pairs 27,113,738 to 27,124,893
The PIGV gene is located on the short (p) arm of chromosome 1 at position 36.11.
More precisely, the PIGV gene is located from base pair 27,113,738 to base pair 27,124,893 on chromosome 1.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about PIGV?
You and your healthcare professional may find the following resources about PIGV helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the PIGV gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding PIGV?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.