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Reviewed February 2011
What is the official name of the PLAGL1 gene?
The official name of this gene is “pleiomorphic adenoma gene-like 1.”
PLAGL1 is the gene's official symbol. The PLAGL1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the PLAGL1 gene?
The PLAGL1 gene provides instructions for making a member of a protein family called zinc finger proteins. Zinc finger proteins are involved in many cellular functions. These proteins each contain one or more short regions called zinc finger domains, which include a specific pattern of protein building blocks (amino acids) and one or more charged atoms of zinc (zinc ions).
Zinc finger proteins attach (bind) primarily to DNA. In most cases, they attach to regions near certain genes and turn the genes on and off as needed. Proteins that bind to DNA and regulate the activity of particular genes are known as transcription factors. Some zinc finger proteins can also bind to other molecules, including RNA (a chemical cousin of DNA) and proteins.
The PLAGL1 protein helps regulate the cell's process for replicating itself in an organized, step-by-step fashion (cell cycle), and is involved in the self-destruction of cells (apoptosis). It is also important in fetal growth. The PLAGL1 protein helps control another protein called the pituitary adenylate cyclase-activating polypeptide receptor (PACAP1). One of the functions of the PACAP1 protein is to stimulate insulin secretion by beta cells in the pancreas. Insulin controls how much glucose (a type of sugar) is passed from the blood into cells for conversion to energy.
PLAGL1 is a paternally expressed imprinted gene, which means that normally only the copy of the gene that comes from the father is active. The copy of the gene that comes from the mother is inactivated (silenced) by a mechanism called methylation.
How are changes in the PLAGL1 gene related to health conditions?
Where is the PLAGL1 gene located?
Cytogenetic Location: 6q24-q25
Molecular Location on chromosome 6: base pairs 143,940,299 to 144,064,598
The PLAGL1 gene is located on the long (q) arm of chromosome 6 between positions 24 and 25.
More precisely, the PLAGL1 gene is located from base pair 143,940,299 to base pair 144,064,598 on chromosome 6.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about PLAGL1?
You and your healthcare professional may find the following resources about PLAGL1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the PLAGL1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding PLAGL1?
acids ; adenoma ; apoptosis ; cancer ; cell ; cell cycle ; chromosome ; diabetes ; diabetes mellitus ; DNA ; duplication ; expressed ; gene ; gene silencing ; glucose ; hormone ; immune system ; insulin ; ions ; maternal ; methylation ; neonatal ; ovarian ; pancreas ; prenatal ; promoter ; protein ; receptor ; RNA ; secretion ; stress ; transcription ; transformation ; transient ; uniparental disomy
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (12 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.