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Reviewed March 2008
What is the official name of the PLP1 gene?
The official name of this gene is “proteolipid protein 1.”
PLP1 is the gene's official symbol. The PLP1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the PLP1 gene?
The PLP1 gene provides instructions for producing proteolipid protein 1 and a modified version (isoform) of proteolipid protein 1, called DM20. Proteolipid protein 1 and DM20 are primarily located in the brain and spinal cord (central nervous system) and are the main proteins found in myelin. Myelin is the fatty covering that insulates nerve fibers and promotes the rapid transmission of nerve impulses. DM20 is primarily involved in the formation of myelin before birth, while proteolipid protein 1 is the predominant protein after birth.
How are changes in the PLP1 gene related to health conditions?
Where is the PLP1 gene located?
Cytogenetic Location: Xq22
Molecular Location on the X chromosome: base pairs 103,031,438 to 103,047,547
The PLP1 gene is located on the long (q) arm of the X chromosome at position 22.
More precisely, the PLP1 gene is located from base pair 103,031,438 to base pair 103,047,547 on the X chromosome.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about PLP1?
You and your healthcare professional may find the following resources about PLP1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the PLP1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding PLP1?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (10 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.