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PXK

PXK

The information on this page was automatically extracted from online scientific databases.

What is the official name of the PXK gene?

The official name of this gene is “PX domain containing serine/threonine kinase.”

PXK is the gene's official symbol. The PXK gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the PXK gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

This gene encodes a phox (PX) domain-containing protein which may be involved in synaptic transmission and the ligand-induced internalization and degradation of epidermal growth factors. Variations in this gene may be associated with susceptibility to systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

From UniProtThis link leads to a site outside Genetics Home Reference.:

Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity.

How are changes in the PXK gene related to health conditions?

Genetics Home Reference provides information about rheumatoid arthritis, which is associated with changes in the PXK gene.
OMIM.orgThis link leads to a site outside Genetics Home Reference., a catalog designed for genetics professionals and researchers, provides the following information about the PXK gene and its association with health conditions.
OMIM
Number
Title

Where is the PXK gene located?

Cytogenetic Location: 3p14.3

Molecular Location on chromosome 3: base pairs 58,332,889 to 58,426,126

The PXK gene is located on the short (p) arm of chromosome 3 at position 14.3.

The PXK gene is located on the short (p) arm of chromosome 3 at position 14.3.

More precisely, the PXK gene is located from base pair 58,332,889 to base pair 58,426,126 on chromosome 3.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about PXK?

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the PXK gene or gene products?

  • MONaKA

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding PXK?

alternative splicing ; degradation ; domain ; gene ; kinase ; ligand ; lupus ; Na ; protein ; SLE ; splicing ; susceptibility ; systemic lupus ; systemic lupus erythematosus ; transcript

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Published: November 24, 2014