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Reviewed December 2009
What is the official name of the RARS2 gene?
The official name of this gene is “arginyl-tRNA synthetase 2, mitochondrial.”
RARS2 is the gene's official symbol. The RARS2 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the RARS2 gene?
The RARS2 gene provides instructions for making an enzyme called mitochondrial arginyl-tRNA synthetase. This enzyme is active in cell structures called mitochondria. Each cell contains hundreds or thousands of mitochondria, which convert the energy from food into a form that cells can use.
Within mitochondria, mitochondrial arginyl-tRNA synthetase interacts with a molecule called transfer RNA (tRNA). This molecule, which is a chemical cousin of DNA, helps assemble protein building blocks called amino acids into functioning proteins. To build new proteins, tRNA must collect different amino acids and then attach them to one another in the correct order. Mitochondrial arginyl-tRNA synthetase is one of several enzymes that link amino acids to tRNA. Specifically, this enzyme links the amino acid arginine to the tRNA molecule, which then incorporates it into new proteins in mitochondria.
How are changes in the RARS2 gene related to health conditions?
Where is the RARS2 gene located?
Cytogenetic Location: 6q16.1
Molecular Location on chromosome 6: base pairs 88,223,655 to 88,299,734
The RARS2 gene is located on the long (q) arm of chromosome 6 at position 16.1.
More precisely, the RARS2 gene is located from base pair 88,223,655 to base pair 88,299,734 on chromosome 6.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about RARS2?
You and your healthcare professional may find the following resources about RARS2 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the RARS2 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding RARS2?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (3 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.