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Reviewed January 2010
What is the official name of the REN gene?
The official name of this gene is “renin.”
REN is the gene's official symbol. The REN gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the REN gene?
The REN gene provides instructions for making a protein called renin, which is produced in the kidneys. This protein is part of the renin-angiotensin system, which regulates blood pressure and water levels in the body. Renin converts a molecule called angiotensinogen into angiotensin. Angiotensin causes blood vessels to narrow (constrict), which results in increased blood pressure. Angiotensin also stimulates the production of the hormone aldosterone, which causes the kidneys to retain salt and water. An increased amount of fluid in the body also increases blood pressure.
How are changes in the REN gene related to health conditions?
Where is the REN gene located?
Cytogenetic Location: 1q32
Molecular Location on chromosome 1: base pairs 204,123,943 to 204,135,464
The REN gene is located on the long (q) arm of chromosome 1 at position 32.
More precisely, the REN gene is located from base pair 204,123,943 to base pair 204,135,464 on chromosome 1.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about REN?
You and your healthcare professional may find the following resources about REN helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the REN gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding REN?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (5 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.