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Reviewed November 2008
What is the official name of the RMRP gene?
The official name of this gene is “RNA component of mitochondrial RNA processing endoribonuclease.”
RMRP is the gene's official symbol. The RMRP gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the RMRP gene?
Unlike many genes, the RMRP gene does not contain instructions for making a protein. Instead, a molecule called a noncoding RNA, a chemical cousin of DNA, is produced from the RMRP gene. This RNA attaches (binds) to several proteins, forming an enzyme called mitochondrial RNA-processing endoribonuclease, or RNase MRP.
The RNase MRP enzyme is thought to be involved in several important processes in the cell. For example, it likely helps copy (replicate) the DNA found in the energy-producing centers of cells (mitochondria). The RNase MRP enzyme probably also processes ribosomal RNA, which is required for assembling protein building blocks (amino acids) into functioning proteins. In addition, this enzyme helps control the cell cycle, which is the cell's way of replicating itself in an organized, step-by-step fashion.
How are changes in the RMRP gene related to health conditions?
Where is the RMRP gene located?
Cytogenetic Location: 9p21-p12
Molecular Location on chromosome 9: base pairs 35,657,747 to 35,658,014
The RMRP gene is located on the short (p) arm of chromosome 9 between positions 21 and 12.
More precisely, the RMRP gene is located from base pair 35,657,747 to base pair 35,658,014 on chromosome 9.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about RMRP?
You and your healthcare professional may find the following resources about RMRP helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the RMRP gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding RMRP?
acids ; adenine ; cancer ; cartilage ; cell ; cell cycle ; deficiency ; DNA ; dwarfism ; dysplasia ; enzyme ; gene ; guanine ; hypoplasia ; hypotrichosis ; immune system ; mitochondria ; molecule ; mutation ; nucleotide ; population ; protein ; ribosomal RNA ; RNA ; short stature ; stature
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (15 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.