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RPL21

RPL21

The information on this page was automatically extracted from online scientific databases.

What is the official name of the RPL21 gene?

The official name of this gene is “ribosomal protein L21.”

RPL21 is the gene's official symbol. The RPL21 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the RPL21 gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L21E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

How are changes in the RPL21 gene related to health conditions?

UniProtThis link leads to a site outside Genetics Home Reference. provides the following information about the RPL21 gene's known or predicted involvement in human disease.

Defects in RPL21 are a cause of generalized hypotrichosis simplex (HTS). A rare form of non-syndromic hereditary hypotrichosis without characteristic hair shaft anomalies. Affected individuals typically show normal hair at birth, but hair loss and thinning of the hair shaft start during early childhood and progress with age.

NCBI GeneThis link leads to a site outside Genetics Home Reference. lists the following diseases or traits (phenotypes) known or believed to be associated with changes in the RPL21 gene.
  • HYPOTRICHOSIS 12[1]This link leads to a site outside Genetics Home Reference.
UniProt and NCBI Gene cite these articles in OMIM, a catalog designed for genetics professionals and researchers that provides detailed information about genetic conditions and genes.
 Article
Number
Main Topic
[1]

Where is the RPL21 gene located?

Cytogenetic Location: 13q12.2

Molecular Location on chromosome 13: base pairs 27,251,554 to 27,256,567

The RPL21 gene is located on the long (q) arm of chromosome 13 at position 12.2.

The RPL21 gene is located on the long (q) arm of chromosome 13 at position 12.2.

More precisely, the RPL21 gene is located from base pair 27,251,554 to base pair 27,256,567 on chromosome 13.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about RPL21?

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the RPL21 gene or gene products?

  • HYPT12
  • L21

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding RPL21?

cytoplasm ; gene ; genome ; hereditary ; hypotrichosis ; protein ; ribosomes ; RNA ; subunit ; synthesis

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Published: July 28, 2014