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SERPINA6

SERPINA6

Reviewed March 2014

What is the official name of the SERPINA6 gene?

The official name of this gene is “serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6.”

SERPINA6 is the gene's official symbol. The SERPINA6 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the SERPINA6 gene?

The SERPINA6 gene provides instructions for making a protein called corticosteroid-binding globulin (CBG), which is primarily produced in the liver. The CBG protein attaches (binds) to a hormone called cortisol, which has numerous functions, such as maintaining blood sugar levels, protecting the body from stress, and suppressing inflammation. When cortisol is bound to CBG, the hormone is turned off (inactive). Normally, around 80 to 90 percent of the body's cortisol is bound to CBG, 5 to 10 percent is unbound and active, and the remaining cortisol is bound to another protein called albumin. When cortisol is needed in the body, CBG delivers the cortisol to the appropriate tissues and releases it, causing cortisol to become active. In this manner, CBG regulates the amount of cortisol that is available for use in the body. The amount of total cortisol in the body consists of both bound (inactive) and unbound (active) cortisol.

Does the SERPINA6 gene share characteristics with other genes?

The SERPINA6 gene belongs to a family of genes called SERPIN (serine (or cysteine) peptidase inhibitors).

A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.

How are changes in the SERPINA6 gene related to health conditions?

corticosteroid-binding globulin deficiency - caused by mutations in the SERPINA6 gene

More than 10 mutations in the SERPINA6 gene have been found to cause corticosteroid-binding globulin deficiency. This condition can cause extreme tiredness (fatigue), low blood pressure (hypotension), or chronic pain. However, some people with this condition do not experience any symptoms.

The mutations that cause corticosteroid-binding globulin deficiency often decrease the CBG protein's ability to bind to cortisol; some severe mutations prevent the production of any CBG protein. With less functional CBG to bind cortisol, people with corticosteroid-binding globulin deficiency usually have increased unbound cortisol levels. Typically, the body decreases cortisol production to compensate, resulting in a reduction in total cortisol.

It is unclear how a decrease in CBG protein and total cortisol leads to the signs and symptoms of corticosteroid-binding globulin deficiency. Since the CBG protein is needed to transport cortisol to specific tissues at certain times, it may be that while cortisol is available in the body, the cortisol is not getting to the tissues that require it. A decrease in cortisol may influence widening or narrowing of the blood vessels, contributing to abnormal blood pressure. Some researchers think the features may influence each other and that fatigue could be a result of chronic pain rather than a symptom of the disorder itself. There may also be other genetic or environmental factors that influence whether an affected individual is more likely to develop pain or fatigue.

other disorders - increased risk from variations of the SERPINA6 gene

A normal variation (polymorphism) in the SERPINA6 gene has been associated with an increased risk of developing chronic fatigue syndrome. This condition involves prolonged episodes of extreme tiredness (fatigue) that can last for months and interfere with daily activities, as well as general symptoms, such as sore throat or headaches. The SERPINA6 gene polymorphism associated with chronic fatigue syndrome replaces the protein building block (amino acid) alanine with the amino acid serine at position 224 in the CBG protein (written as Ala224Ser or A224S). This change likely increases the amount of CBG protein that is available. It is unknown how increasing CBG protein levels contributes to the risk of developing chronic fatigue syndrome, but it is likely that many other factors, both genetic and environmental, contribute to the development of this complex disorder.

Where is the SERPINA6 gene located?

Cytogenetic Location: 14q32.1

Molecular Location on chromosome 14: base pairs 94,304,247 to 94,323,350

The SERPINA6 gene is located on the long (q) arm of chromosome 14 at position 32.1.

The SERPINA6 gene is located on the long (q) arm of chromosome 14 at position 32.1.

More precisely, the SERPINA6 gene is located from base pair 94,304,247 to base pair 94,323,350 on chromosome 14.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about SERPINA6?

You and your healthcare professional may find the following resources about SERPINA6 helpful.

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the SERPINA6 gene or gene products?

  • CBG
  • CBG_HUMAN
  • corticosteroid binding globulin
  • corticosteroid-binding globulin
  • serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
  • serpin A6
  • transcortin

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding SERPINA6?

alanine ; amino acid ; chronic ; cysteine ; deficiency ; gene ; hormone ; hypotension ; inflammation ; polymorphism ; protein ; proteinase ; serine ; stress ; symptom ; syndrome

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

References (6 links)

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Reviewed: March 2014
Published: July 21, 2014