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Reviewed September 2009
What is the official name of the SERPINA7 gene?
The official name of this gene is “serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7.”
SERPINA7 is the gene's official symbol. The SERPINA7 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the SERPINA7 gene?
The SERPINA7 gene (also known as TBG) provides instructions for making a protein called thyroxine-binding globulin. In the bloodstream, this protein carries hormones made or used by the thyroid gland, which is a butterfly-shaped tissue in the lower neck. Thyroid hormones play an important role in regulating growth, brain development, and the rate of chemical reactions in the body (metabolism). Most of the time, thyroid hormones circulate in the bloodstream attached to thyroxine-binding globulin and similar proteins.
Does the SERPINA7 gene share characteristics with other genes?
The SERPINA7 gene belongs to a family of genes called SERPIN (serine (or cysteine) peptidase inhibitors).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the SERPINA7 gene related to health conditions?
Where is the SERPINA7 gene located?
Cytogenetic Location: Xq22.2
Molecular Location on the X chromosome: base pairs 105,277,189 to 105,282,717
The SERPINA7 gene is located on the long (q) arm of the X chromosome at position 22.2.
More precisely, the SERPINA7 gene is located from base pair 105,277,189 to base pair 105,282,717 on the X chromosome.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about SERPINA7?
You and your healthcare professional may find the following resources about SERPINA7 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the SERPINA7 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding SERPINA7?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.