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Reviewed April 2011
What is the official name of the SGCA gene?
The official name of this gene is “sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein).”
SGCA is the gene's official symbol. The SGCA gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the SGCA gene?
The SGCA gene provides instructions for making the alpha component (subunit) of a group of proteins called the sarcoglycan protein complex. The sarcoglycan protein complex is located in the membrane surrounding muscle cells. It helps maintain the structure of muscle tissue by attaching (binding) to and stabilizing the dystrophin complex, which is made up of proteins called dystrophins and dystroglycans. The large dystrophin complex strengthens muscle fibers and protects them from injury as muscles tense (contract) and relax. It acts as an anchor, connecting each muscle cell's structural framework (cytoskeleton) with the lattice of proteins and other molecules outside the cell (extracellular matrix).
How are changes in the SGCA gene related to health conditions?
Where is the SGCA gene located?
Cytogenetic Location: 17q21
Molecular Location on chromosome 17: base pairs 48,243,365 to 48,253,292
The SGCA gene is located on the long (q) arm of chromosome 17 at position 21.
More precisely, the SGCA gene is located from base pair 48,243,365 to base pair 48,253,292 on chromosome 17.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about SGCA?
You and your healthcare professional may find the following resources about SGCA helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the SGCA gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding SGCA?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (11 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.