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Reviewed February 2011
What is the official name of the SLC12A3 gene?
The official name of this gene is “solute carrier family 12 (sodium/chloride transporters), member 3.”
SLC12A3 is the gene's official symbol. The SLC12A3 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the SLC12A3 gene?
The SLC12A3 gene provides instructions for making a protein known as NCC. This protein is a sodium chloride co-transporter, which means that it moves charged atoms (ions) of sodium (Na+) and chlorine (Cl-) across cell membranes.
The NCC protein is essential for normal kidney function. It is part of the mechanism by which kidneys reabsorb salt (sodium chloride or NaCl) from the urine back into the bloodstream. The retention of salt affects the body's fluid levels and helps maintain blood pressure.
Does the SLC12A3 gene share characteristics with other genes?
The SLC12A3 gene belongs to a family of genes called SLC (solute carriers).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the SLC12A3 gene related to health conditions?
Where is the SLC12A3 gene located?
Cytogenetic Location: 16q13
Molecular Location on chromosome 16: base pairs 56,899,118 to 56,949,761
The SLC12A3 gene is located on the long (q) arm of chromosome 16 at position 13.
More precisely, the SLC12A3 gene is located from base pair 56,899,118 to base pair 56,949,761 on chromosome 16.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about SLC12A3?
You and your healthcare professional may find the following resources about SLC12A3 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the SLC12A3 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding SLC12A3?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (11 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.