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Reviewed September 2010
What is the official name of the SLC37A4 gene?
The official name of this gene is “solute carrier family 37 (glucose-6-phosphate transporter), member 4.”
SLC37A4 is the gene's official symbol. The SLC37A4 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the SLC37A4 gene?
The SLC37A4 gene provides instructions for making a protein called glucose 6-phosphate translocase. This protein transports the sugar molecule glucose 6-phosphate from the fluid inside the cell (cytoplasm) to the endoplasmic reticulum, which is a structure inside cells that is involved in protein processing and transport. At the membrane of the endoplasmic reticulum, glucose 6-phosphate translocase works together with the glucose 6-phosphatase protein (produced from the G6PC gene) to break down glucose 6-phosphate. The breakdown of this molecule produces the simple sugar glucose, which is the primary energy source for most cells in the body.
Does the SLC37A4 gene share characteristics with other genes?
The SLC37A4 gene belongs to a family of genes called SLC (solute carriers).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the SLC37A4 gene related to health conditions?
Where is the SLC37A4 gene located?
Cytogenetic Location: 11q23.3
Molecular Location on chromosome 11: base pairs 118,895,060 to 118,901,615
The SLC37A4 gene is located on the long (q) arm of chromosome 11 at position 23.3.
More precisely, the SLC37A4 gene is located from base pair 118,895,060 to base pair 118,901,615 on chromosome 11.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about SLC37A4?
You and your healthcare professional may find the following resources about SLC37A4 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the SLC37A4 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding SLC37A4?
acids ; carrier ; cell ; cytoplasm ; endoplasmic reticulum ; gene ; gluconeogenesis ; glucose ; glycogen ; molecule ; neutropenia ; phosphatase ; phosphate ; protein ; simple sugar ; solute ; toxic ; white blood cells
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.