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SNCAIP

SNCAIP

The information on this page was automatically extracted from online scientific databases.

What is the official name of the SNCAIP gene?

The official name of this gene is “synuclein, alpha interacting protein.”

SNCAIP is the gene's official symbol. The SNCAIP gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the SNCAIP gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of only two have been determined. [provided by RefSeq, Jul 2011]

From UniProtThis link leads to a site outside Genetics Home Reference.:

Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1.

How are changes in the SNCAIP gene related to health conditions?

NCBI GeneThis link leads to a site outside Genetics Home Reference. lists the following diseases or traits (phenotypes) known or believed to be associated with changes in the SNCAIP gene.
  • Parkinson's disease
OMIM.orgThis link leads to a site outside Genetics Home Reference., a catalog designed for genetics professionals and researchers, provides the following information about the SNCAIP gene and its association with health conditions.
OMIM
Number
Title

Where is the SNCAIP gene located?

Cytogenetic Location: 5q23.2

Molecular Location on chromosome 5: base pairs 122,311,348 to 122,464,098

The SNCAIP gene is located on the long (q) arm of chromosome 5 at position 23.2.

The SNCAIP gene is located on the long (q) arm of chromosome 5 at position 23.2.

More precisely, the SNCAIP gene is located from base pair 122,311,348 to base pair 122,464,098 on chromosome 5.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about SNCAIP?

You and your healthcare professional may find the following resources about SNCAIP helpful.

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the SNCAIP gene or gene products?

  • Sph1
  • SYPH1

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding SNCAIP?

ATP ; atypical ; bradykinesia ; degradation ; dementia ; domain ; etiology ; familial ; family history ; gene ; GTP ; isoforms ; Lewy bodies ; ligase ; motif ; mutation ; protein ; sporadic ; substantia nigra ; susceptibility ; tissue ; transcript ; tremor ; ubiquitin

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Published: April 13, 2015