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Reviewed August 2012
What is the official name of the SOD1 gene?
The official name of this gene is “superoxide dismutase 1, soluble.”
SOD1 is the gene's official symbol. The SOD1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the SOD1 gene?
The SOD1 gene provides instructions for making an enzyme called superoxide dismutase, which is abundant in cells throughout the body. This enzyme attaches (binds) to molecules of copper and zinc to break down toxic, charged oxygen molecules called superoxide radicals. Superoxide radicals can damage cells if too many accumulate within cells. Superoxide radicals are byproducts of normal cell processes, particularly energy-producing reactions, and must be broken down regularly.
How are changes in the SOD1 gene related to health conditions?
Where is the SOD1 gene located?
Cytogenetic Location: 21q22.11
Molecular Location on chromosome 21: base pairs 33,031,934 to 33,041,243
The SOD1 gene is located on the long (q) arm of chromosome 21 at position 22.11.
More precisely, the SOD1 gene is located from base pair 33,031,934 to base pair 33,041,243 on chromosome 21.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about SOD1?
You and your healthcare professional may find the following resources about SOD1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the SOD1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding SOD1?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (9 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.