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Reviewed February 2011
What is the official name of the SPRED1 gene?
The official name of this gene is “sprouty-related, EVH1 domain containing 1.”
SPRED1 is the gene's official symbol. The SPRED1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the SPRED1 gene?
The SPRED1 gene provides instructions for making the Spred-1 protein, which helps control (regulate) the Ras/MAPK signaling pathway. The Ras/MAPK pathway is involved in the growth and division of cells (proliferation), the process by which cells mature to carry out specific functions (differentiation), cell movement, and the self-destruction of cells (apoptosis).
The Spred-1 protein attaches (binds) to a protein called Raf, which is part of the Ras/MAPK pathway. The binding of the Spred-1 protein blocks the activation of Raf, stopping the signaling through the remainder of the Ras/MAPK pathway.
How are changes in the SPRED1 gene related to health conditions?
Where is the SPRED1 gene located?
Cytogenetic Location: 15q14
Molecular Location on chromosome 15: base pairs 38,252,723 to 38,357,248
The SPRED1 gene is located on the long (q) arm of chromosome 15 at position 14.
More precisely, the SPRED1 gene is located from base pair 38,252,723 to base pair 38,357,248 on chromosome 15.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about SPRED1?
You and your healthcare professional may find the following resources about SPRED1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the SPRED1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding SPRED1?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (7 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.