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Reviewed August 2007
What is the official name of the STK11 gene?
The official name of this gene is “serine/threonine kinase 11.”
STK11 is the gene's official symbol. The STK11 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the STK11 gene?
The STK11 gene (also called LKB1) provides instructions for making an enzyme called serine/threonine kinase 11. This enzyme is a tumor suppressor, which means that it helps keep cells from growing and dividing too fast or in an uncontrolled way. In addition to its role in regulating cell division, this enzyme helps certain types of cells correctly orient themselves within tissues (polarization) and assists in determining the amount of energy a cell uses. This kinase also promotes a type of programmed cell death known as apoptosis. Through a combination of these mechanisms, serine/threonine kinase 11 aids in the prevention of tumors, especially in the gastrointestinal tract, pancreas, cervix, ovaries, and breasts. Serine/threonine kinase 11 function is also required for normal development before birth.
How are changes in the STK11 gene related to health conditions?
Where is the STK11 gene located?
Cytogenetic Location: 19p13.3
Molecular Location on chromosome 19: base pairs 1,205,798 to 1,228,434
The STK11 gene is located on the short (p) arm of chromosome 19 at position 13.3.
More precisely, the STK11 gene is located from base pair 1,205,798 to base pair 1,228,434 on chromosome 19.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about STK11?
You and your healthcare professional may find the following resources about STK11 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the STK11 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding STK11?
acids ; apoptosis ; cancer ; carcinoma ; cell ; cell division ; enzyme ; gastrointestinal ; gene ; hamartomatous ; kinase ; melanoma ; pancreas ; pancreatic ; protein ; serine ; syndrome ; threonine ; threonine kinase ; tumor
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (15 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.