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Reviewed October 2012
What is the official name of the SURF1 gene?
The official name of this gene is “surfeit 1.”
SURF1 is the gene's official symbol. The SURF1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the SURF1 gene?
The SURF1 gene provides instructions for making a protein that is important in oxidative phosphorylation, the process by which the energy from food is converted into a form cells can use. Oxidative phosphorylation involves a series of reactions that take place through several different protein complexes. The SURF1 protein aids in the correct assembly of one of the protein complexes, or enzymes, involved in oxidative phosphorylation called complex IV.
Complex IV, also known as cytochrome c oxidase or COX, accepts negatively charged particles (electrons) from earlier steps in oxidative phosphorylation. In addition, the enzyme accepts positively charged particles (protons) from inside the mitochondrion. Using the electrons and protons, the COX enzyme performs a chemical reaction that converts oxygen to water. The enzyme also transfers additional protons across the specialized membrane inside the mitochondrion. These processes create energy that is used to generate ATP, the cell's main energy source.
How are changes in the SURF1 gene related to health conditions?
Genetics Home Reference provides information about cytochrome c oxidase deficiency, which is also associated with changes in the SURF1 gene.
Where is the SURF1 gene located?
Cytogenetic Location: 9q34.2
Molecular Location on chromosome 9: base pairs 136,218,665 to 136,223,360
The SURF1 gene is located on the long (q) arm of chromosome 9 at position 34.2.
More precisely, the SURF1 gene is located from base pair 136,218,665 to base pair 136,223,360 on chromosome 9.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about SURF1?
You and your healthcare professional may find the following resources about SURF1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the SURF1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding SURF1?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.