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Reviewed December 2008
What is the official name of the TAF1 gene?
The official name of this gene is “TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa.”
TAF1 is the gene's official symbol. The TAF1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the TAF1 gene?
The TAF1 gene provides instructions for making part of a protein called transcription factor IID (TFIID). This protein is active in cells and tissues throughout the body, where it attaches (binds) to DNA. Transcription factor IID plays an essential role in regulating the activity of most genes.
The TAF1 gene is part of a complex region of DNA known as the TAF1/DYT3 multiple transcript system. This region consists of short stretches of DNA from the TAF1 gene plus some extra segments of genetic material near the gene. These stretches of DNA can be combined in different ways to create various sets of instructions for making proteins. Researchers believe that some of these variations are critical for the normal function of nerve cells (neurons) in the brain.
Does the TAF1 gene share characteristics with other genes?
The TAF1 gene belongs to a family of genes called chromatin-modifying enzymes (chromatin-modifying enzymes).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the TAF1 gene related to health conditions?
Where is the TAF1 gene located?
Cytogenetic Location: Xq13.1
Molecular Location on the X chromosome: base pairs 71,366,238 to 71,530,524
The TAF1 gene is located on the long (q) arm of the X chromosome at position 13.1.
More precisely, the TAF1 gene is located from base pair 71,366,238 to base pair 71,530,524 on the X chromosome.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about TAF1?
You and your healthcare professional may find the following resources about TAF1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the TAF1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding TAF1?
caudate ; caudate nucleus ; cell ; cell cycle ; DNA ; dystonia ; gene ; insertion ; nucleotide ; nucleus ; parkinsonism ; protein ; putamen ; retrotransposon ; RNA ; RNA polymerase ; subunit ; transcript ; transcription ; transcription factor
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.