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Reviewed August 2008
What is the official name of the TBP gene?
The official name of this gene is “TATA box binding protein.”
TBP is the gene's official symbol. The TBP gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the TBP gene?
The TBP gene provides instructions for making a protein called the TATA box binding protein. This protein is active in cells and tissues throughout the body, where it plays an essential role in regulating the activity of most genes.
The TATA box binding protein attaches (binds) to a particular sequence of DNA known as the TATA box. This sequence occurs in a regulatory region of DNA near the beginning of many genes. Once the protein is attached to the TATA box near a gene, it acts as a landmark to indicate where other enzymes should start reading the gene. The process of reading a gene's DNA and transferring the information to a similar molecule called mRNA is known as transcription.
One region of the TBP gene contains a particular DNA segment known as a CAG/CAA trinucleotide repeat. This segment is made up of a series of three DNA building blocks (nucleotides) that appear multiple times in a row. Normally, the CAG/CAA segment is repeated 25 to 42 times within the gene.
How are changes in the TBP gene related to health conditions?
Where is the TBP gene located?
Cytogenetic Location: 6q27
Molecular Location on chromosome 6: base pairs 170,863,383 to 170,881,957
The TBP gene is located on the long (q) arm of chromosome 6 at position 27.
More precisely, the TBP gene is located from base pair 170,863,383 to base pair 170,881,957 on chromosome 6.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about TBP?
You and your healthcare professional may find the following resources about TBP helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the TBP gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding TBP?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.