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Reviewed May 2006
What is the official name of the TG gene?
The official name of this gene is “thyroglobulin.”
TG is the gene's official symbol. The TG gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the TG gene?
The TG gene provides instructions for making a protein called thyroglobulin, one of the largest proteins in the body. This protein is found only in the thyroid gland, a butterfly-shaped tissue in the lower neck. Thyroglobulin combines with iodine and is modified and broken down to release small molecules known as thyroid hormones. Thyroid hormones play an important role in regulating growth, brain development, and the rate of chemical reactions in the body (metabolism). Thyroglobulin also serves as a protein storehouse for iodine and inactive thyroid hormone until these substances are needed.
How are changes in the TG gene related to health conditions?
Genetics Home Reference provides information about these additional conditions, which are also associated with changes in the TG gene:
Where is the TG gene located?
Cytogenetic Location: 8q24
Molecular Location on chromosome 8: base pairs 133,879,148 to 134,147,145
The TG gene is located on the long (q) arm of chromosome 8 at position 24.
More precisely, the TG gene is located from base pair 133,879,148 to base pair 134,147,145 on chromosome 8.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about TG?
You and your healthcare professional may find the following resources about TG helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the TG gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding TG?
autoimmune ; autoimmunity ; bacteria ; congenital ; deficiency ; DNA ; gene ; goiter ; hormone ; hypothyroidism ; immune response ; iodine ; metabolism ; protein ; TGN ; thyroglobulin ; thyroid ; thyroid hormones ; tissue
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (12 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.