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Reviewed April 2011
What is the official name of the TINF2 gene?
The official name of this gene is “TERF1 (TRF1)-interacting nuclear factor 2.”
TINF2 is the gene's official symbol. The TINF2 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the TINF2 gene?
The TINF2 gene provides instructions for making part of the shelterin protein complex. This complex consists of a group of proteins that work together to help maintain structures known as telomeres, which are found at the ends of chromosomes. Telomeres help protect chromosomes from abnormally sticking together or breaking down (degrading).
The shelterin complex helps protect telomeres from the cell's DNA repair process. Without the protection of shelterin, the repair mechanism would sense the chromosome ends as abnormal breaks in the DNA sequence and either attempt to join the ends together or initiate cellular self-destruction (apoptosis).
How are changes in the TINF2 gene related to health conditions?
Where is the TINF2 gene located?
Cytogenetic Location: 14q12
Molecular Location on chromosome 14: base pairs 24,703,453 to 24,712,232
The TINF2 gene is located on the long (q) arm of chromosome 14 at position 12.
More precisely, the TINF2 gene is located from base pair 24,703,453 to base pair 24,712,232 on chromosome 14.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about TINF2?
You and your healthcare professional may find the following resources about TINF2 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the TINF2 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding TINF2?
acids ; anemia ; aplastic anemia ; apoptosis ; bone marrow ; cancer ; cell ; chromosome ; DNA ; DNA repair ; fibrosis ; gene ; leukoplakia ; mucosa ; pigmentation ; protein ; pulmonary ; syndrome ; telomere
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (11 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.