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Reviewed February 2010
What is the official name of the TNFRSF11B gene?
The official name of this gene is “tumor necrosis factor receptor superfamily, member 11b.”
TNFRSF11B is the gene's official symbol. The TNFRSF11B gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the TNFRSF11B gene?
The TNFRSF11B gene provides instructions for making a protein called osteoprotegerin. This protein plays an important role in bone remodeling, a normal process in which old bone is broken down and new bone is created to replace it. Osteoprotegerin is involved in the regulation of specialized cells called osteoclasts, which break down bone tissue during bone remodeling.
Osteoprotegerin is one of two receptor proteins that can attach (bind) to a protein called receptor activator of NF-κB ligand (RANKL). The other receptor protein is called receptor activator of NF-κB (RANK). Because RANKL can only bind to one receptor at a time, osteoprotegerin and RANK compete with one another. When RANKL is bound to RANK, it sets off a series of chemical signals that trigger immature osteoclasts to mature and become fully functional. When RANKL is bound to osteoprotegerin, it blocks these chemical signals and prevents the activation of osteoclasts. Because no chemical signals are transmitted when RANKL is attached to osteoprotegerin, osteoprotegerin is often called a "decoy" receptor.
By reducing the amount of RANKL that is available to bind to RANK, osteoprotegerin plays a critical role in regulating the process of bone remodeling.
Does the TNFRSF11B gene share characteristics with other genes?
The TNFRSF11B gene belongs to a family of genes called TNFRSF (tumor necrosis factor receptor superfamily).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the TNFRSF11B gene related to health conditions?
Where is the TNFRSF11B gene located?
Cytogenetic Location: 8q24
Molecular Location on chromosome 8: base pairs 119,935,795 to 119,964,382
The TNFRSF11B gene is located on the long (q) arm of chromosome 8 at position 24.
More precisely, the TNFRSF11B gene is located from base pair 119,935,795 to base pair 119,964,382 on chromosome 8.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about TNFRSF11B?
You and your healthcare professional may find the following resources about TNFRSF11B helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the TNFRSF11B gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding TNFRSF11B?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (9 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.