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Reviewed March 2010
What is the official name of the TNFRSF13B gene?
The official name of this gene is “tumor necrosis factor receptor superfamily, member 13B.”
TNFRSF13B is the gene's official symbol. The TNFRSF13B gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the TNFRSF13B gene?
The TNFRSF13B gene provides instructions for making a protein called transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI). The TACI protein is found on the cell membrane of B cells. B cells are specialized white blood cells that help protect the body against infection. When B cells mature, they produce special proteins called antibodies (which are also known as immunoglobulins). These proteins attach to specific foreign particles and germs, marking them for destruction. Through interactions with other proteins, TACI promotes cell signaling and plays a role in B cell survival and maturation. TACI is also involved in the production of antibodies.
Does the TNFRSF13B gene share characteristics with other genes?
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the TNFRSF13B gene related to health conditions?
Where is the TNFRSF13B gene located?
Cytogenetic Location: 17p11.2
Molecular Location on chromosome 17: base pairs 16,842,397 to 16,875,431
The TNFRSF13B gene is located on the short (p) arm of chromosome 17 at position 11.2.
More precisely, the TNFRSF13B gene is located from base pair 16,842,397 to base pair 16,875,431 on chromosome 17.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about TNFRSF13B?
You and your healthcare professional may find the following resources about TNFRSF13B helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the TNFRSF13B gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding TNFRSF13B?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (7 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.