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Reviewed December 2009
What is the official name of the TSEN34 gene?
The official name of this gene is “tRNA splicing endonuclease 34 homolog (S. cerevisiae).”
TSEN34 is the gene's official symbol. The TSEN34 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the TSEN34 gene?
The TSEN34 gene provides instructions for making one part (subunit) of an enzyme called the tRNA splicing endonuclease complex. This complex helps process several types of RNA molecules, which are chemical cousins of DNA.
The tRNA splicing endonuclease complex is particularly important for the normal processing of a form of RNA known as transfer RNA (tRNA). tRNA molecules help assemble protein building blocks known as amino acids into full-length proteins. However, before they can assemble proteins, tRNAs must be processed into mature molecules. In particular, some tRNA molecules contain regions called introns that need to be removed for the tRNAs to be functional. The tRNA splicing endonuclease complex recognizes and then removes introns to help produce mature tRNA molecules.
Studies suggest that the tRNA splicing endonuclease complex may also be involved in processing another form of RNA known as messenger RNA (mRNA). mRNA serves as a genetic blueprint for making proteins. Researchers suspect that the tRNA splicing endonuclease complex cuts (cleaves) one end of mRNA molecules so a string of adenines (one of the building blocks of RNA) can be added. This process is known as polyadenylation, and the string of adenines is known as a poly(A) tail. The poly(A) tail signals the stopping point for protein production and protects mRNA from being broken down before protein production occurs.
How are changes in the TSEN34 gene related to health conditions?
Where is the TSEN34 gene located?
Cytogenetic Location: 19q13.4
Molecular Location on chromosome 19: base pairs 54,694,118 to 54,698,393
The TSEN34 gene is located on the long (q) arm of chromosome 19 at position 13.4.
More precisely, the TSEN34 gene is located from base pair 54,694,118 to base pair 54,698,393 on chromosome 19.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about TSEN34?
You and your healthcare professional may find the following resources about TSEN34 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the TSEN34 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding TSEN34?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (5 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.