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Reviewed July 2009
What is the official name of the UROS gene?
The official name of this gene is “uroporphyrinogen III synthase.”
UROS is the gene's official symbol. The UROS gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the UROS gene?
The UROS gene provides instructions for making an enzyme known as uroporphyrinogen III synthase. This enzyme is involved in the production of a molecule called heme. Heme is vital for all of the body's organs, although it is most abundant in the blood, bone marrow, and liver. Heme is an essential component of iron-containing proteins called hemoproteins, including hemoglobin (the protein that carries oxygen in the blood).
The production of heme is a multi-step process that requires eight different enzymes. Uroporphyrinogen III synthase is responsible for the fourth step in this process, in which hydroxymethylbilane (the product of the third step) is rearranged to form uroporphyrinogen III. In subsequent steps, four other enzymes produce and modify compounds that ultimately lead to heme.
How are changes in the UROS gene related to health conditions?
Where is the UROS gene located?
Cytogenetic Location: 10q25.2-q26.3
Molecular Location on chromosome 10: base pairs 127,477,146 to 127,511,836
The UROS gene is located on the long (q) arm of chromosome 10 between positions 25.2 and 26.3.
More precisely, the UROS gene is located from base pair 127,477,146 to base pair 127,511,836 on chromosome 10.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about UROS?
You and your healthcare professional may find the following resources about UROS helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the UROS gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding UROS?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (11 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.