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Reviewed November 2013
What is the official name of the WDR35 gene?
The official name of this gene is “WD repeat domain 35.”
WDR35 is the gene's official symbol. The WDR35 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the WDR35 gene?
The WDR35 gene (also known as IFT121) provides instructions for making a protein that is involved in the formation and maintenance of cilia, which are microscopic, finger-like projections that stick out from the surface of cells. Cilia participate in signaling pathways that transmit information within and between cells and are important for the development and function of many types of cells and tissues, including cells in the kidneys and liver and the light-sensitive tissue at the back of the eye (the retina). Cilia also play a role in the development of the bones, although the mechanism is not well understood.
The movement of substances within cilia and similar structures called flagella is known as intraflagellar transport. This process is essential for the assembly and maintenance of these cell structures. During intraflagellar transport, cells use molecules called IFT particles to carry materials to and from the tips of cilia. Each IFT particle is made up of two groups of IFT proteins: complex A and complex B. The protein produced from the WDR35 gene forms part of IFT complex A (IFT-A). During intraflagellar transport, this complex carries materials from the tip to the base of cilia.
The IFT-A complex is essential for proper regulation of the Sonic Hedgehog signaling pathway, which is important for the growth and maturation (differentiation) of cells and the normal shaping (patterning) of many parts of the body, especially during embryonic development. The exact role of the complex in this pathway is unclear.
Does the WDR35 gene share characteristics with other genes?
The WDR35 gene belongs to a family of genes called WDR (WD repeat domain containing).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the WDR35 gene related to health conditions?
Where is the WDR35 gene located?
Cytogenetic Location: 2p24.1
Molecular Location on chromosome 2: base pairs 19,910,259 to 19,990,122
The WDR35 gene is located on the short (p) arm of chromosome 2 at position 24.1.
More precisely, the WDR35 gene is located from base pair 19,910,259 to base pair 19,990,122 on chromosome 2.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about WDR35?
You and your healthcare professional may find the following resources about WDR35 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the WDR35 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding WDR35?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.