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Reviewed July 2014
What is the official name of the WNT4 gene?
The official name of this gene is “wingless-type MMTV integration site family, member 4.”
WNT4 is the gene's official symbol. The WNT4 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the WNT4 gene?
The WNT4 gene belongs to a family of WNT genes that play critical roles in development before birth. WNT genes provide instructions for making proteins that participate in chemical signaling pathways in the body. These pathways control the activity of certain genes and regulate the interactions between cells during embryonic development.
The WNT4 gene provides instructions for producing a protein that is important for the formation of the female reproductive system, the kidneys, and several hormone-producing glands. During the development of the female reproductive system, the WNT4 protein regulates the formation of the Müllerian ducts, which are structures in the embryo that develop into the uterus, fallopian tubes, cervix, and the upper part of the vagina. This protein is also involved in development of the ovaries, from before birth through adulthood, and is important for development and maintenance of egg cells (oocytes) in the ovaries. In addition, the WNT4 protein regulates the production of male sex hormones (androgens).
Does the WNT4 gene share characteristics with other genes?
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the WNT4 gene related to health conditions?
Where is the WNT4 gene located?
Cytogenetic Location: 1p36.23-p35.1
Molecular Location on chromosome 1: base pairs 22,117,304 to 22,143,025
The WNT4 gene is located on the short (p) arm of chromosome 1 between positions 36.23 and 35.1.
More precisely, the WNT4 gene is located from base pair 22,117,304 to base pair 22,143,025 on chromosome 1.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about WNT4?
You and your healthcare professional may find the following resources about WNT4 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the WNT4 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding WNT4?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (14 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.