A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other.
For more information, see What are gene families? in the Handbook.
The following families, defined by the HUGO Gene Nomenclature Committee
, are included in Genetics Home Reference.
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ABC (ATP-binding cassette transporters)
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ABHD (abhydrolase domain containing genes)
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ADAMTS (ADAMTS metallopeptidase with thrombospondin type 1 motif family)
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ALDH (aldehyde dehydrogenases)
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ATP (ATPase superfamily)
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blood group (blood group determining genes)
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CACN (calcium channels)
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CD (CD molecules)
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COLPG (collagen proteoglycans)
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CTS (cathepsins)
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CYP (cytochrome P450)
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DNAJ (DnaJ (Hsp40) homologs)
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FOX (Forkhead box genes)
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FZD (frizzled homologs)
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GJ (gap junction proteins (connexins))
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GPC (glypicans)
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GPR (G protein-coupled receptors)
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HLA (histocompatibility complex genes)
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IFT (intraflagellar transport homologs)
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IL (interleukin and interleukin receptor genes)
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KCN (potassium channels)
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KIF (kinesins)
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KRT (keratins)
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NLR (nucleotide-binding domain and leucine rich repeat containing family)
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PAX (paired box gene)
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PTP (protein tyrosine phosphatases)
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RPS (ribosomal proteins)
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SCN (sodium channels)
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SERPIN (serine (or cysteine) proteinase inhibitors)
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SLC (solute carriers)
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SLRR (small leucine-rich repeat family)
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SMAD (SMAD, mothers against DPP homologs)
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SOX (SRY (sex determining region Y)-box genes)
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TNFSF (Tumor necrosis factor (ligand) superfamily)
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TRIM (tripartite motif-containing)
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USP (ubiquitin-specific peptidases)
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WNT (wingless-type MMTV integration site family)
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ZFYVE (zinc fingers, FYVE-type)
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ZNF (zinc fingers, C2H2-type)
