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CATSPER gene family

Reviewed April 2010

What are the CATSPER genes?

Genes in the cation channels, sperm associated (CATSPER) family provide instructions for making proteins that are embedded in the membrane of sperm cells. These proteins are channels that regulate the entry of positively charged calcium atoms (calcium cations) into sperm cells. Calcium cations are required for a type of sperm motility called hyperactivation. Hyperactivation is characterized by vigorous movements of the sperm tail (flagellum), which are necessary for the sperm to push through the membrane of the egg cell during fertilization.

Mutations in genes in the CATSPER gene family can result in sperm abnormalities and an inability to father children (male infertility).

Which genes are included in the CATSPER gene family?

The HUGO Gene Nomenclature Committee (HGNC) provides a list of genes in the CATSPER familyThis link leads to a site outside Genetics Home Reference..

Genetics Home Reference summarizes the normal function and health implications of these members of the CATSPER gene family: CATSPER1 and CATSPER2.

What conditions are related to genes in the CATSPER gene family?

Genetics Home Reference includes these conditions related to genes in the CATSPER gene family:

Where can I find additional information about the CATSPER gene family?

You may find the following resources about the CATSPER gene family helpful.

Where can I find general information about genes and gene families?

The Handbook provides basic information about genetics in clear language.

What glossary definitions help with understanding the CATSPER gene family?

calcium ; cation ; cell ; channel ; egg ; gene ; infertility ; sperm

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

References (3 links)

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Reviewed: April 2010
Published: July 21, 2014