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The CD genes belong to a large family of genes called the cluster of differentiation. Many CD genes provide instructions for making proteins that are found on the surface of white blood cells (leukocytes) at various stages of their development. These proteins help the white blood cells interact with the body's tissues and attack bacteria, viruses, and other invaders.
Other members of the CD gene family work outside of the immune system. For example, some CD genes play a role in cell signaling and the development of the nervous system.
Most of the genes in this family are designated by the letters CD and a number corresponding to the specific gene within the family, such as CD132. Many of the genes in the CD gene family also have other names that may be more commonly used. For example, the CD132 gene is also called IL2RG.
The HUGO Gene Nomenclature Committee (HGNC) provides a list of genes in the CD family (http://www.genenames.org/genefamily/cd.php).
Genetics Home Reference summarizes the normal function and health implications of these members of the CD gene family: ACE, ALK, BMPR1A, CD40LG, CDH1, CSF1R, ENG, ERBB2, FAS, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, FZD4, IL2RG, IL7R, ITGA6, ITGB2, ITGB4, JAG1, KIT, L1CAM, LAMP2, MPL, MUC1, PDGFRA, PRNP, TNFRSF1A, TNFRSF11A, and TNFRSF13B.
Genetics Home Reference includes these conditions related to genes in the CD gene family:
You may find the following resources about the CD gene family helpful.
adhesion molecule ; antigens ; bacteria ; cell ; cell adhesion ; class ; differentiation ; enzyme ; epithelial ; FAS ; fibroblast ; gene ; growth factor ; immune system ; kinase ; leukemia ; ligand ; lymphoma ; molecule ; necrosis ; nervous system ; oncogene ; prion ; protein ; receptor ; sarcoma ; subunit ; tumor ; tyrosine ; virus ; white blood cells
You may find definitions for these and many other terms in the Genetics Home Reference Glossary (http://www.ghr.nlm.nih.gov/glossary).
These sources were used to develop the Genetics Home Reference summary for the CD gene family.
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.