|http://ghr.nlm.nih.gov/ A service of the U.S. National Library of Medicine®|
The COLPG genes provide instructions for making the protein component of large molecules called collagen proteoglycans. A proteoglycan is a molecule that is made up of a core protein attached to one or more sugar molecules called glycosaminoglycan (GAG) chains. The COLPG gene family is a subset of a larger gene family known as the proteoglycan superfamily.
The many different types of proteoglycans are classified according to their core protein. The core protein produced by members of the COLPG gene family is collagen. Collagens are a family of proteins that strengthen and support connective tissues, such as skin, bone, cartilage, tendons, and ligaments. Collagen proteoglycans are major components of the extracellular matrix, which is an intricate lattice of proteins and other molecules that forms in the spaces between cells. The collagen proteoglycans bind to a variety of other proteins in the extracellular matrix, including other forms of collagen.
The HUGO Gene Nomenclature Committee (HGNC) provides a list of genes in the COLPG family (http://www.genenames.org/genefamilies/proteoglycan).
Genetics Home Reference summarizes the normal function and health implications of these members of the COLPG gene family: COL9A1, COL9A2, and COL9A3.
Genetics Home Reference includes these conditions related to genes in the COLPG gene family:
You may find the following resources about the COLPG gene family helpful.
cartilage ; collagen ; extracellular ; extracellular matrix ; gene ; molecule ; protein ; proteoglycan
You may find definitions for these and many other terms in the Genetics Home Reference Glossary (http://www.ghr.nlm.nih.gov/glossary).
These sources were used to develop the Genetics Home Reference summary for the COLPG gene family.
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.