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DYN gene family

Reviewed January 2013

What are the DYN genes?

Genes in the DYN family provide instructions for making proteins that form a group (complex) called a cytoplasmic dynein. This complex is found in the fluid inside cells (cytoplasm) and is known as a cytoplasmic dynein complex. This complex is turned on (activated) by attaching (binding) to another complex called dynactin. This dynein-dynactin complex binds to various materials within cells. Using energy provided from molecules called ATP, the dynein-dynactin complex moves its bound material along a track-like system of small tubes called microtubules, similar to a conveyer belt. The dynein-dynactin complex is necessary for protein transport, positioning of cell compartments, mobility of structures within the cell, and many other cell processes. In nerve cells (neurons), the dynein-dynactin complex helps neighboring cells communicate by transporting sac-like structures called synaptic vesicles that contain chemical messengers. When synaptic vesicles are passed from one neuron to another, dynein transports the vesicle from the edge of the cell to the center where the chemical message is received.

The parts (subunits) of a cytoplasmic dynein complex are produced from 15 known genes. These subunits are classified by weight as heavy, intermediate, light intermediate, or light chains. Two heavy chain proteins bind together to form the core of the dynein complex. Combinations of intermediate, light intermediate, and light chains make up the rest of the complex.

Which genes are included in the DYN gene family?

The HUGO Gene Nomenclature Committee (HGNC) provides a list of genes in the DYN familyThis link leads to a site outside Genetics Home Reference..

Genetics Home Reference summarizes the normal function and health implications of this member of the DYN gene family: DYNC1H1.

What conditions are related to genes in the DYN gene family?

Genetics Home Reference includes these conditions related to genes in the DYN gene family:

Where can I find additional information about the DYN gene family?

Where can I find general information about genes and gene families?

The Handbook provides basic information about genetics in clear language.

What glossary definitions help with understanding the DYN gene family?

ATP ; cell ; cytoplasm ; neuron ; protein ; synaptic vesicles ; vesicle

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

References (4 links)

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Reviewed: January 2013
Published: October 27, 2014