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Genetics Home Reference: your guide to understanding genetic conditions
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RPS gene family

Reviewed February 2012

What are the RPS genes?

Genes in the RPS family provide instructions for making some of the approximately 80 different ribosomal proteins, which are components of cellular structures called ribosomes. Ribosomes process the cell's genetic instructions to create new proteins.

Each ribosome is made up of two parts (subunits) called the large and small subunits. The subunits each consist of multiple ribosomal proteins and RNA, a chemical cousin of DNA. The proteins produced from members of the RPS gene family are found in the small subunit.

The specific functions of the individual ribosomal proteins within the small subunit are unclear. Some ribosomal proteins are involved in the assembly or stability of ribosomes. Others help carry out the ribosome's main function of building new proteins. Studies suggest that some ribosomal proteins may have other functions, such as participating in chemical signaling pathways within the cell, regulating cell division, and controlling the self-destruction of cells (apoptosis).

Which genes are included in the RPS gene family?

The HUGO Gene Nomenclature Committee (HGNC) provides a list of genes in the RPS family (http://www.genenames.org/genefamily/rps.php).

Genetics Home Reference summarizes the normal function and health implications of these members of the RPS gene family: RPS7, RPS10, RPS17, RPS19, RPS24, and RPS26.

What conditions are related to genes in the RPS gene family?

Genetics Home Reference includes these conditions related to genes in the RPS gene family:

  • Diamond-Blackfan anemia

Where can I find additional information about the RPS gene family?

You may find the following resources about the RPS gene family helpful.

  • Molecular Biology of the Cell (fourth edition, 2002): The RNA Message Is Decoded on Ribosomes (http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=mboc4&part=A1052)
  • The Cell: A Molecular Approach (second edition, 2000): Ribosome Assembly (figure) (http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cooper&part=A1372&rendertype=figure&id=A1372)

What glossary definitions help with understanding the RPS gene family?

apoptosis ; cell ; cell division ; DNA ; gene ; protein ; ribosomes ; RNA ; subunit

You may find definitions for these and many other terms in the Genetics Home Reference Glossary (http://www.ghr.nlm.nih.gov/glossary).

References

These sources were used to develop the Genetics Home Reference summary for the RPS gene family.

  • Perry RP. Balanced production of ribosomal proteins. Gene. 2007 Oct 15;401(1-2):1-3. Epub 2007 Jul 18. Review. (http://www.ncbi.nlm.nih.gov/pubmed/17689889?dopt=Abstract)
  • Wilson DN, Nierhaus KH. Ribosomal proteins in the spotlight. Crit Rev Biochem Mol Biol. 2005 Sep-Oct;40(5):243-67. Review. (http://www.ncbi.nlm.nih.gov/pubmed/16257826?dopt=Abstract)
  • Brodersen DE, Nissen P. The social life of ribosomal proteins. FEBS J. 2005 May;272(9):2098-108. Review. (http://www.ncbi.nlm.nih.gov/pubmed/15853795?dopt=Abstract)
  • Dresios J, Panopoulos P, Synetos D. Eukaryotic ribosomal proteins lacking a eubacterial counterpart: important players in ribosomal function. Mol Microbiol. 2006 Mar;59(6):1651-63. Review. (http://www.ncbi.nlm.nih.gov/pubmed/16553873?dopt=Abstract)
  • Bhavsar RB, Makley LN, Tsonis PA. The other lives of ribosomal proteins. Hum Genomics. 2010 Jun;4(5):327-44. Review. (http://www.ncbi.nlm.nih.gov/pubmed/20650820?dopt=Abstract)

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.

 
Reviewed: February 2012
Published: December 16, 2014